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These factors are also used to predict success in patients with relapsed or persistent HD who are undergoing stem cell transplantation.

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The hemoglobin levels over time are shown in Figure 2 Mean Monthly Hemoglobin Levels (Panel A) and Mean Weekly Doses of Epoetin Alfa (Panel B).

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Treatment of Anemia among Women with Chronic Kidney Disease in United States Outpatient Settings.

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Future perspectives on treatment with erythropoiesis-stimulating agents in high-risk patients.

However, on the basis of safety concerns raised by the FDA and in view of identified side effects, this review further concluded that ESAs should not be used in clinical practice for fatigue.

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This occurs because of reduced production of ammonia, decreased filtration of titratable acids (e.

Hedenus et al randomized 67 patients with lymphoproliferative malignancies not receiving chemotherapy to IV iron sucrose or no iron supplement.

The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD.

Treatments for relapse include chemotherapy, radiation, and bone marrow or blood stem cell transplantation.

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Correcting Anemia in Heart Failure: The Efficacy and Safety of Erythropoiesis-Stimulating Agents.

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PRCA and severe anemia, with or without other cytopenias, associated with neutralizing antibodies to erythropoietin have been reported, especially in patients with chronic kidney disease.

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Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation.

Erythropoietin and the Control of Red Cell Production.

Withdrawal of erythropoietic stimulation, particularly when Hb levels are high, results in an unusually low eEpo level, a reduced number of reticulocytes and RBC macrocytes, and increases in ferritin and total circulating iron.

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Your doctor will adjust your dose of darbepoetin alfa injection so that your hemoglobin level (amount of a protein found in red blood cells) is just high enough that you do not need a red blood cell transfusion (transfer of one person's red blood cells to another person's body to treat severe anemia).

The modifying effect of iron on Hb response to ESA was represented by multiplicative interaction between the iron marker and change in ESA dose term in the model equation.

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The use of epoetin and darbepoetin is one way to treat anemia caused by chemotherapy, when used according to the FDA-approved label.

Prognostic implications of anemia with or without chronic kidney disease in patients undergoing elective percutaneous coronary intervention.

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Permanently discontinue epoetin alfa in patients who develop PRCA following treatment with epoetin alfa or other erythropoietin protein drugs.

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Care of patients with CKD requires a multifaceted approach, with focus on close monitoring of GFR and aggressive institution of measures aimed at slowing progression of the disease.

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Red blood cell transfusion and not epoetin alfa (EPO) should be the preferred approach in treating patients with and anemia, according to a study published in the Journal of Clinical Oncology.

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